B ai HQ b ai t ai i g used i ENACT Study
LONDON, July 13, 2026 (GLOBE NEWSWIRE) — The same b ai t ai i g show i the past i e mo ths to educe the i cide ce of Alzheime ’s i the ACTIVE Study a d to ejuve ate the p oductio of the b ai chemical acetylcholi e (k ow to plummet with Alzheime ’s) i the INHANCE Study, has ow bee show to imp ove beta amyloid bioma ke s, a key i dicato of Alzheime ’s, i a study p ese ted today at the Alzheime ’s Associatio I te atio al Co fe e ce i Lo do . The ew esults a e to be published as a abst act i a suppleme t to Alzheime ‘s & Deme tia, The Jou al of the Alzheime ’s Associatio . The b ai exe cises achievi g these esults (ofte efe ed to as “speed” o “speed of p ocessi g” t ai i g”) a e available exclusively as pa t of the b ai fit ess app, B ai HQ f om Posit Scie ce.
The ewly a ou ced esults a e f om the ENACT (Elucidati g the Necessa y Active Compo e ts of T ai i g) Study, a a domized co t olled t ial, which evaluated whethe compute ized cog itive t ai i g could alte blood-based bioma ke s associated with deme tia isk. Pa ticipa ts ( = 53) we e a domized to 20 hou s of t ai i g o eithe B ai HQ o compute games (such as Wo d Sea ch). A alyses exami ed bioma ke cha ges befo e a d afte t ai i g. The esea che s epo ted a sig ifica t imp oveme t i Aβ42/Aβ40 atios followi g speed t ai i g, suggesti g that this fo m of cog itive t ai i g may i flue ce biological pathways i volved i eu odege e atio . Bioma ke cha ges va ied by sex, co siste t with a g owi g body of evide ce that me a d wome espo d diffe e tly to Alzheime ’s- elated the apies, such as amyloid-ta geti g d ugs a d choli este ase i hibito s.
“The ENACT Study esea che s have u what we believe to be the fi st study to exami e the elatio ship betwee b ai t ai i g a d levels of beta amyloid,” obse ved D . He y Mah cke, a leade i eu oplasticity esea ch a d the CEO of Posit Scie ce, which makes a d ma kets the B ai HQ b ai exe cise app used i the ENACT Study.
“To ma y these esults will be su p isi g,” D . Mah cke co ti ued, “but take togethe with the ACTIVE a d INHANCE studies published ove the past i e mo ths, they tell a ve y cohe e t a d impo ta t sto y of a majo evolutio i ou thi ki g about Alzheime ’s, which shows the biological paths by which plasticity-based t ai i g ca emodel the b ai to slow a d eve eve se cog itive agi g a d offe some p otectio agai st deme tia.”
The NIH-fu ded, 2800-pe so , ACTIVE Study 20-yea follow-up, published i Feb ua y, ea ed headli es a ou d the globe with its fi di g that speed t ai i g (exclusively available i B ai HQ) educed diag oses of Alzheime ’s, as epo ted i Medica e eco ds ove 20 yea s, by 25% (with just 23 hou s, i total, of t ai i g, sp ead ove the fi st th ee yea s).
The NIH-fu ded INHANCE Study, published i Novembe , also ga e ed global p ess, whe esea che s at McGill U ive sity used adva ced eu oimagi g i a a domized co t olled t ial to t ack whethe 10 weeks of B ai HQ exe cises had a y impact o the p oductio of acetylcholi e (the “pay atte tio ” b ai chemical), k ow to dow egulate at a accele ati g ate with agi g a d to plummet with deme tia. While acetylcholi e has lo g bee a ta get of Alzheime ’s esea ch, o i te ve tio othe tha B ai HQ has bee show to up egulate its p oductio i a ma e that pe sists afte the i te ve tio . The McGill esea che s epo ted that followi g 10 weeks of t ai i g, the up egulatio was equivale t to about a 10-yea “ ejuve atio ” i acetylcholi e p oductio .
Take togethe with the ew ENACT study esults, these studies suppo t a ew path beyo d ta geti g emovi g “plaques a d ta gles”— lo g the p ima y ide tifie s of Alzheime ’s a d fo decades the p ima y focus of Alzheime ’s esea ch spe di g.
“Collectively, these studies show the ight ki d of b ai t ai i g ca up egulate acetylcholi e p oductio , imp ovi g the choli e gic system, a d, th ough the choli e gic a ti-i flammato y pathway, educi g Alzheime ’s- elated pathologies, like amyloid.”
“I believe a sy thesis of these th ee ece t b eakth ough studies should fu the shift esou ces to deme tia p eve tio a d especially to the ole of ha essi g eu oplasticity to educe i flammatio , to up egulate eu omodulatio , a d to imp ove biological esilie ce of the b ai as a o ga . We view eu oplasticity as a key co t ibuto to what some call ‘cog itive ese ve’ — the ability of the b ai to esist deme tia.” D . Mah cke added.
B ai HQ exe cises have show be efits i mo e tha 300 studies. Such be efits i clude gai s i cog itio (atte tio , speed, memo y, decisio -maki g), i quality of life (dep essive symptoms, co fide ce a d co t ol, health- elated quality of life) a d i eal-wo ld activities (health outcomes, bala ce, d ivi g, wo kplace activities). B ai HQ is used by leadi g health a d Medica e Adva tage pla s, by leadi g medical ce te s, cli ics, a d commu ities, a d by elite athletes, the milita y, a d othe o ga izatio s focused o peak pe fo ma ce. Co sume s ca t y a B ai HQ exe cise fo f ee daily at b ai hq.com.
A photo accompa yi g this a ou ceme t is available at https://www.globe ewswi e.com/NewsRoom/Attachme tNg/de5c0048-5865-4b8a-919e-951e3350a6f0
